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Basic Science and Translational Research

The research in the Movement Disorders Division is led by , the Chief of the Division. Dr. Khurana also leads the Precision Neurology Program at Brigham and Women’s Hospital, which includes an American Parkinson Disease Center for Advanced Research (APDA CAR). Current research efforts have a unified goal: to develop treatments for patients with degenerative movement disorders, including Parkinson’s disease, atypical Parkinsonian syndromes such as and , and .

Benefitting from expertise in biological profiling, biospecimen banking and stem-cell biology, we seek to develop approaches to establish precise treatment options tailored to specific patients.

Laboratory research in the Division occurs in the setting of Laboratories and a number of Translational and Basic Science Initiatives that bring us together with multiple partnering laboratories at Brigham and Women’s Hospital, Harvard Medical School and beyond:

We collaborate with academic laboratories within the Ann Romney Center for Neurologic Diseases focused on Parkinson’s disease and related disorders, and also with industry. These collaborations help move our vision forward toward executing clinical trials in stratified, well-defined patient population.

A centerpiece of our research efforts includes the Harvard Biomarker Study that is currently enrolling patients with neurodegenerative disorders and healthy controls.

Dr. Michael D. Fox in the Division leads the cross-department that develops new treatments for patients with brain disease by directly targeting brain networks responsible for neurological and psychiatric symptoms.

Translational and Basic Science Initiatives - collaborative efforts centered specifically on Movement Disorders

InitiativesLead InvestigatorsCo-Investigator
Dr. Barbara Changizi, Dr. Saranna Fanning
Barbara Bloom Ranson Program in MSA Research
Brigham Research Institute Transformative Grant
Functional Neurosurgery and Gene Therapy
Department of Defense: Gene-Environment Interactions in Parkinson’s DiseaseDr. Laurie Cox, Dr. Howard Weiner, Dr. Vikram Khurana
Aligning Science Across Parkinson’s Initiative (1)
Dr. Changning WangDr. Stephen Gomperts, Dr. Vikram Khurana
Gene regulation and Parkinson’s disease – NIH R01 Dr. Erinc HallacliDr. Vikram Khurana
Alpha-synuclein aggregation biology (NIH R01s x 2)Dr. Ulf DettmerDr. Vikram Khurana
APDA Center for Advanced Research Dr. Vikram KhuranaDr. Daniel El-Kodsi
Toward personalized circuit therapy in OCD (Foundation Grant, R01)Dr. Andreas HornDr. Mike Fox, Dr. Darin Dougherty, Dr. Rees Cosgrove
Using causal sources of information to map an epilepsy circuit (R01)
Using brain connectivity to identify causal neuroanatomical substrate of depression symptoms (R01)
Testing utility of an ultra-high resolution connectome for deep brain stimulation mapping (UM1)Dr. Anastasía Yendiki

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