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Department of Pathology

About Our Pathology Research

The research laboratories of the Department encompass a wide variety of areas and emphasize a modern, multi-disciplinary approach to pathophysiology and mechanisms of disease. Selected examples of current activities in the areas of emphasis in the basic research groups of the Department of Pathology at 91精品l are:

Research Areas

Cardiac Pathology

Research topics include: Cardiovascular dysfunction and cardiac device malfunction

Faculty


Vice Chair, Education, BWH
Professor of Pathology, HMS
Research Interests: transplantation pathology, cardiac and vascular pathology, immune-vessels


Associate Pathologist, BWH
Associate Professor of Pathology, HMS


Executive Vice Chair, Pathology, BWH
Professor of Pathology, HMS
Research Interests: Host-biomaterial interactions, clinicopathologic correlations in heart valve.

Diseases of the Female Reproductive System

Research topics include: cervical and vulvular diseases, ovarian cancer and fallopian tubes, uterine leiomyoma, Endometrial Disease Research, and genetics of endometrial cancer

Faculty


Senior Pathologist, BWH
Professor of Pathology, HMS
Research Interests: Cell of origin and its relevance to prevention or early detection in gynecologic.


Chief, GU Pathology, BWH
Associate Professor of Pathology, HMS


Senior Pathologist, BWH
Professor of Pathology, HMS
Research Interests: carcinogenesis, endometrial cancer, gynecologic cancer, biomarkers

Vice Chair, Women’s and Perinatal Pathology, BWH
Professor of Pathology, HMS


Associate Pathologist, BWH
Associate Professor of Pathology, HMS
Research Interests: Mesenchymal neoplasia of the female genital tract

Genetic Basis of Inherited Disorders

Research topics include: genetic hearing loss, and structural genomic variation, chromosomal abnormalities in cancer

Faculty

Associate Cytogeneticist, BWH
Professor of Pathology, HMS

Anne Giersch, PhD
Associate Cytogeneticist, BWH
Assistant Professor of Pathology, HMS
Research Interests: The genetics of hearing, deafness, and age related hearing loss


Director, Clinical Cytogenetics, BWH
Associate Professor of Pathology, HMS


Director, Cytogenetics Research, BWH
Professor of Genetics and Pathology, BWH
Research Interests: Hereditary Deafness, Uterine Leiomyomata, Developmental Disorders


Associate Molecular Geneticist, BWH
Professor of Pathology, HMS
Research Interests: genomic medicine; molecular diagnostic test development; hearing loss

Immunology

Research topics include: Cellular interactions in immune responses, immunology of vascular endothelium, cytokines, lymphocyte activation and tolerance, targeted disruption of lymphocyte molecules, autoimmunity, and antigen presentation.

Faculty


Associate Professor, BWH
Associate Professor of Pathology, HMS
Research Interests: Metagenomics, Microbiome, Pathology Informatics, Clinical Microbiology


Associate Professor, HMS
Research Interests: Regulation of Mucosal Immunity


Senior Pathologist, BWH
Professor of Pathology, HMS
Research Interests: Immunology, Vascular Biology, Cardiovascular Disease

Scott B. Lovitch, MD, PhD
Associate Pathologist, BWH
Assistant Professor of Pathology, HMS
Research Interests: Immunology, immunometabolism, costimulation, immunoregulation


Scientist, BWH
Professor of Pathology, HMS
Research Interests: Innate immune mechanisms of tissue injury; leukocyte recruitment


Vice Chair, Education, BWH
Professor of Pathology, HMS
Research Interests: transplantation pathology, cardiac and vascular pathology, immune-vessels


Vice Chair, Transfusion Medicine
Professor of Pathology, HMS
Research Interests: Cell Manipulation, Transfusion Medicine, Haematopoietic stem cells


Senior Scientist, BWH
Co-Director of HITI, HMS

Infections Disease

Research Interests: Role and function of innate-like T Cells (CD1d-restricted....more

Faculty


Associate Pathologist, BWH
Assistant Professor of Pathology, HMS
Research Interests: Role and function of innate-like T Cells (CD1d-restricted.

Associate Pathologist, BWH
Assistant Professor of Pathology, HMS
Research Interests: computational and systems biology, synthetic biology, microbiome


Director, Microbiology, BWH
Professor of Pathology, HMS
Research Interests: Role of the human microbiome in health and disease.

Molecular Oncology

Research topics include: Molecular studies of oncogenes and tumor suppressor genes, analysis of chromosomal aberrations in cancer and benign disorders, control of DNA synthesis and the cell cycle, mechanisms of gene transcription, immunogenetics, receptor mediated control of cell differentiation, signal transduction, and molecular methods of disease diagnosis

Faculty


Chief, Hematopathology, BWH
Professor of Pathology, HMS
Research Interests: oncogenic role of Notch signaling in T-cell acute lymphoblastic leukemia (T-ALL) and other cancers


Associate Pathologist, BWH
Associate Professor of Pathology, HMS
Research Interests: Cancer, stem cells, genetics and epigenetic, translation


Associate Pathologist, BWH
Assistant Professor of Pathology, HMS


Director, Hematology, BWH
Professor of Pathology, HMS


Cytogeneticist, BWH
Associate Professor, HMS
Research Interests: Tumor biology of sarcoma, mesothelioma and pediatric solid cancers


Associate Pathologist, BWH
Associate Professor, HMS
Research Interests: Oncogenic mechanisms; NUT midline carcinoma; cytopathology


Associate Pathologist, BWH
Associate Professor of Pathology, HMS
Research Interests: Cancer, brain tumors, stem cell, clinical trials


Senior Pathologist, BWH
Professor of Pathology, HMS
Research Interests: The role of lipid metabolism in prostate cancer and on metabolic profiling.

Matthew Meryerson, PhD
Professor of Pathology, HMS
Research Interests: Cancer genomics, cancer biology and targeted therapies


Pathologist, BWH
Professor of Pathology, HMS
Research Interests: molecular pathological epidemiology


Associate Pathologist, BWH
Associate Professor of Pathology, HMS


Research Scientist, BWH
Associate Professor of Pathology, HMS
Research Interests: Genitourinary malignancies. Genitourinary tract development.


Associate Pathologist, BWH
Assistant Professor of Pathology, HMS

Giorgia Zadra, PhD
Instructor of Pathology, HMS
Research Interests: prostate cancer metabolism

Molecular Pathology

Faculty


Professor of Medicine and Pathology, HMS
Research Interests: transcription factors, TF-DNA interactions, transcriptional enhancers

Pulmonary Pathobiology

Research topics include: Mechanisms of inhalant-induced lung injury, the biology of alveolar macrophages, pathogenesis of mesothelioma and the molecular basis of lung development, including neuroendocrine differentiation.

Faculty


Associate Pathologist, BWH
Associate Professor of Pathology, HMS

Neuropathology

Research topics include: Oncogenesis of glial tumors, developmental neurobiology, and neurodegenerative diseases.

Faculty


Neuropathologist, BWH
Professor of Pathology, HMS
Research Interests: Modeled human neurological diseases, including Alzheimer’s Disease

Ginam Cho, PhD
Scientist, BWH
Instructor of Pathology, HMS
Research Interests: forebrain development, ER-mitochondria contact


Associate Pathologist, BWH
Associate Professor of Pathology, HMS
Research Interests: Cancer, brain tumors, stem cell, clinical trials


Associate Pathologist, BWH
Assistant Professor of Pathology, HMS

Skin Disease

Research topics include skin epigenetics and stem cell biology as they relate to graft-versus-host disease, psoriasis, wound healing, chronologic aging, and skin cancer; the immunobiology of face transplant rejection; the cell biology of melanoma precursor pathways; and mechanisms of protein degradation via the ubiquitin-proteasome system.

Faculty


Chair, Dermatopathology, BWH
Professor of Pathology, HMS
Research Interests: cytotoxicity, stem cells, biomarkers

John W. Hanna, MD, PhD
Associate Pathologist, BWH
Assistant Professor of Pathology, HMS
Research Interests: protein degradation, ubiquitin-proteasome system.


Associate Pathologist, BWH
Assistant Professor of Pathology, HMS
Research Interests: Epigenetic regulations of melanoma and skin diseases

Surgical Pathology

Research topics include: Gastrointestinal stromal tumor, inflammatory bowel disease, sarcoma, liposarcomas, and preneoplastic gastrointestinal conditions

Faculty

Tony Agoston, MD, PhD
Associate Pathologist, BWH
Assistant Professor of Pathology, HMS


Chief, Endocrinology, BWH
Associate Professor of Pathology, HMS


Cytogeneticist, BWH
Associate Pathologist, HMS
Research Interests: Tumor biology of sarcoma, mesothelioma and pediatric solid cancers.


Director, Surgical Pathology, BWH
Professor of Pathology, HMS

Elizabeth A. Morgan, MD
Associate Pathologist, BWH
Assistant Professor of Pathology, HMS


Associate Pathologist, BWH
Assistant Professor of Pathology, HMS

Vascular Biology

Research topics include: Leukocyte-endothelial interactions, molecular basis of endothelial gene expression and role of hemodynamic factors, targeted disruption of endothelial adhesion molecules, molecular mechanism of atherosclerosis.

Faculty


Scientist, BWH
Professor of Pathology, HMS
Research Interests: Innate immune mechanisms of tissue injury; leukocyte recruitment


Director, Center of Excellence in Vascular Biology, BWH
Professor of Pathology, HMS
Research Interests: Vascular (patho)biology; endothelium; atherogenesis.


Scientist, BWH
Associate Professor of Pathology, HMS
Research Interests: Molecular, bioengineering, and bioinformatics approaches to understand


Associate Director, Vascular Biology, BWH
Professor of Pathology, HMS
Research Interests: Vascular Cell Biology; Immunology; Leukocyte recruitment.


Scientist, BWH
Assistant Professor of Pathology, HMS
Research Interests: developmental vascular biology